Медикаменты, Алвобак пор. д/ин. 1000 мг фл. №1 В наличии 83.59 грн! (050)490-490-0 (068)111-77-49 (057)766-72-60 (0536)703-226 (0542)79-28-20.

Алвобак пор. д/ин. 1000 мг фл. №1

О продукте Алвобак пор. д/ин. 1000 мг фл. №1

                                   !" #&/

                    4;O <548G=>3> 70AB>AC20==O ?@5?0@0BC


                                  (LVOBAC)


   !:;04:

   4VNG0 @5G>28=0: Aeftriaxon5;

   1 D;0:>= =C =0B@VN 5:2V20;5=B=> F5DB@80:A>=C 1 3.


   V:0@AL:0 D>@<0. >@>H>: 4;O @>7G8=C 4;O V=T:FV9.


   $0@<0:>B5@0?52B8G=0   3@C?0.  =B810:B5@V0;L=V  70A>18  4;O  A8AB5<=>3>
   70AB>AC20==O.   =HV   15B0-;0:B0<=V   0=B81V>B8:8.  &5D0;>A?>@8=8  III
   ?>:>;V==O. &5DB@80:A>=. >4 "! J01D D04.


   ;V=VG=V E0@0:B5@8AB8:8.

   >:070==O.

   V:C20==O V=D5:FV9, 71C4=8:8 O:8E GCB;82V 4> F5DB@80:A>=C:

   V=D5:FVW  48E0;L=8E H;OEV2, >A>1;82> ?=52<>=VO, 0 B0:>6 V=D5:FVW 2CE0,
   3>@;0 V =>A0;

   V=D5:FVW >@30=V2 G5@52=>W ?>@>6=8=8 (?5@8B>=VB, V=D5:FVW 6>2G>282V4=8E
   H;OEV2 V H;C=:>2>-:8H:>2>3> B@0:BC);

   V=D5:FVW =8@>: V A5G>282V4=8E H;OEV2;

   V=D5:FVW AB0B528E >@30=V2, 2:;NG0NG8 3>=>@5N;

   A5?A8A;

   V=D5:FVW :VAB>:, , 0 B0:>6 @0=>2V V=D5:FVW;

   V=D5:FVW C E2>@8E 7 >A;01;5=8< V<;

   <5=V=3VB;

   48A520=89 1>@5;V>7 09<0 (@0==V B0 ?V7=V AB04VW 70E2>@N20==O).

   5@54>?5@0FV9=0  ?@>DV;0:B8:0  V=D5:FV9  ?@8  EV@C@3VG=8E 2B@CG0==OE =0
   >@30=0E  H;C=:>2>-:8H:>2>3> B@0:BC, 6>2G>282V4=8E H;OEV2, A5G>282V4=8E
   H;OEV2  V  ?V4  G0A  3V=5:>;>3VG=8E  ?@>F54C@,  0;5  ;8H5  C  28?04:0E
   ?>B5=FV9=>W G8 2V4><>W :>=B0

   @8  ?@87=0G5==V  F5DB@80:A>=C  =5>1EV4=>  4>B@8DVFV9=8E @5:><5=40FV9 7
   0=B81V>B8:>B5@0?VW,      7>:@5<0     @5:><5=40FV9    7    ?@>DV;0:B8:8
   0=B81V>B8:>@578AB5=B=>ABV.


   @>B8?>:070==O.

   V428I5=0  GCB;82VABL  4>  F5D0;>A?>@8=V2.  0O2=VABL  2 0=0<=57V BO6:8E
   @50:FV9   3V?5@GCB;82>ABV   (=0?@8:;04,   0=0DV;0:B8G=8E  @50:FV9)  4>
   1C4L-O:>3>   V=H>3>   B8?C  15B0-;0:B0<=8E  0=B810:B5@V0;L=8E  70A>1V2
   (?5=VF8;V=V2, <>=>10:B0

   54>=>H5=8<  =>2>=0@>465=8<  2V:><  ?  41 B8645=L V7 2@0EC20==O< AB@>:C
   2=CB@VH=L>CB@>1=>3>    @>728B:C   (35AB0FV9=89   2V:   +   2V:   ?VA;O
   =0@>465==O)*.  V?5@1V;V@C1V=52>=0@>465=8E  B0  =54>=>H5=8E. >A;V465==O
   in vitro ?>:070;8, I> F5DB@80:A>= <>65 28BVA=OB8 1V;V@C1V= 7V 72O7:C 7
   0;L1C<   A8@>20B:8   :@>2V,  I>  <>65  ?@8725AB8  4>  @878:C  @>728B:C
   5=F5D0;>?0BVW, A?@8G8=5=>W 1V;V@C1V=><.



   >=>H5=8< =>2>=0@>465=8< (2V:>< ? 28 4=V2):

   ?@8  6>2BO=8FV,  3V?5@1V;V@C1V=5  3V?>0;L1C7V,  B>  ?@8  B0:8E  AB0=0E
   72O7C20==O 1V;V@C1V=C 70728G09 ?>@CH5=>;

   4;O   70AB>AC20==O   ?@8  =5>1EV4=>ABV  (G8  >GV:C20=V9  =5>1EV4=>ABV)
   ;V:C20==O  2=CB@VH=L>25==8<8  @>7G8=0<8, O:V 25==V 2;820==O, =0?@8:;04
   ?0@5=B5@0;L=5  E0@GC20==O,  C 72O7:C 7 @878:>< 28=8:=5==O ?@5F8?VB0BV2
   :0;LFVT28E  A>;59  F5DB@80:A>=C  (482.  @>74V; «!?>AV1 70AB>AC20==O B0
   4>78»).

   * # 4>A;V465==OE Vn vitro 1C;> ?>:070=>, I> F5DB@80:A>= <>65 28BVA=OB8
   1V;V@C1V=  7V  72O7:C  7  0;L1C<  A8@>20B:8  :@>2V,  I>  ?@872>48BL 4>
   <>6;82>3>   @878:C   @>728B:C   1V;V@C1V=>2>W  5=F5D0;>?0BVW  C  B0:8E
   ?0FVT=BV2.

   5@54  2=CB@VH=L>28<  22545==O<  F5DB@80:A>=C A;V4 >1>2O7:>2> 28:;NG8B8
   =0O2=VABL   ?@>B8?>:070=L   4>   70AB>AC20==O   ;V4>:0W=C,  O:I>  9>3>
   70AB>A>2CNBL    2   O:>ABV   @>7G8==8:0   (482.   @>74V;   «A>1;82>ABV
   70AB>AC20==O»).  82.  V=AB@C:FVN 4;O <548G=>3> 70AB>AC20==O ;V4>:0W=C,
   >A>1;82> ?@>B8?>:070==O.

   >7G8=8 F5DB@80:A>=C, I> :0W=, =V:>;8 =5 A;V4 22>48B8 2=CB@VH=L>25==>.


   !?>AV1 70AB>AC20==O B0 4>78.

   &5DB@80:A>=  <>6=0  70AB>A>2C20B8  C  283;O4V  2=CB@VH=L>28E  V=T:FV9,
   ?>2V;L=8E 2=CB@VH=L>25==8E V=T:FV9 01> 2=CB@VH=L>25==8E V=DC7V9.

   5@54  70AB>AC20==O<  ?@5?0@0BC  =5>1EV4=>  ?@>25AB8  H:V@=89  B5AB  =0
   ?V428I5=C  GCB;82VABL  70  C<>28  2V4ACB=>ABV  ?@>B8?>:070=L  4>  9>3>
   ?@>2545==O.

   5 <>6=0 28:>@8AB>2C20B8 @>7G8==8:8, O:V 7G8= V=35@0 G8 @>7G8= 0@B<0=0,
   4;O  @>7G8=5==O F5DB@80:A>=C C D;0:>=0E G8 4;O @>72545==O 2V4=>2;5=>3>
   @>7G8=C   4;O  2=CB@VH=L>25==>3>  22545==O  C  72O7:C  7  2V@>3V4=VABN
   CB2>@5==O   ?@5F8?VB0BV2   :0;LFVT28E  A>;59  F5DB@80:A>=C.  8=8:=5==O
   ?@5F8?VB0BV2  :0;LFVT28E A>;59 F5DB@80:A>=C B0:>6 <>65 2V41C20B8AL ?@8
   7=C   7   @>7G8=0<8,   O:V   4=V9  V=DC7V9=V9  A8AB525==>3>  22545==O.
   &5DB@80:A>=  =5  <>6=0 74=>G0A=> 22>48B8 7 @>7G8=0<8, O:V 4VO 7 V=H8<8
   ;V:0@AL:8<8 70A>10<8 B0 V=HV 2848 270T<>4V9»).

   >7C20==O  B0  H;OE 22545==O 70;560BL 2V4 BO6:>ABV V=D5:FVW, GCB;82>ABV
   71C4=8:0  B0  AB0=C  ?0FVT=B0.  0728G09 ?@5?0@0B 22>4OBL 1 @07 =0 4>1C
   (:>6=V 24 3>48=8).

   >@>A;V   V   4VB8   2V:><  2V4  12  @>:V2:  70728G09  ?@87=0G0NBL  1 3
   F5DB@80:A>=C 1 @07 =0 4>1C (:>6=V

   24  3>48=8).  @8  BO6:8E  V=D5:FVOE 01> V=D5:FVOE, 71C4=8:8 O:8E <0NBL
   ;8H5 ?> F5DB@80:A>=C, 4>1>2C 4>7C <>6=0 71V;LHC20B8 4> 2-4 3.

   VB8

   >2>=0@>465=V V 4VB8 2V:>< 4> 12 @>:V2

   >2>=0@>465=V  (4>  2  B86=V2):  20-50  <3/:3  <0A8 BV;0 1 @07 =0 4>1C.
   2060NG8 =0 =54>@>728=5=VABL D5@<5=B=>W A8AB5<8, 4>1>20 4>70 =5 ?>28==0
   ?5@528IC20B8   50   <3/:3  <0A8  BV;0.  >2>=0@>465=8<  2=CB@VH=L>25==5
   22545==O  ?>28==>  B@820B8  =5  <5=H5  60  E2, I>1 ?>?5@548B8 @>728B>:
   1V;V@C1V=>2>W 5=F5D0;>?0BVW.

   @5?0@0B ?@>B8?>:070=89 4;O 70AB>AC20==O =>2>=0@>465=8< 2V:>< ? 28 4=V2
   ?@8    =5>1EV4=>ABV    (G8    >GV:C20=V9    =5>1EV4=>ABV)    ;V:C20==O
   2=CB@VH=L>25==8<8  @>7G8=0<8,  O:V  25==V  2;820==O,  O:V < 28=8:=5==O
   ?@5F8?VB0BV2    :0;LFVT28E    A>;59    F5DB@80:A>=C    (482.    @>74V;
   «@>B8?>:070==O»).

   5<>2;OB0  2V:>< 2V4 15 4=V2 V 4VB8 2V:>< 4> 12 @>:V2: 20-80 <3/:3 <0A8
   BV;0 1 @07 =0 4>1C.

   @8  BO6:8E  V=D5:FVOE  4>1>2C  4>7C <>6=0 71V;LHC20B8 4> 80 <3/:3 <0A8
   BV;0 1 @07 =0 4>1C.

   VBO< 7 <0A>N BV;0 ?>=04 50 :3 ?@87=0G0NBL 4>78 4;O 4>@>A;8E.

   =CB@VH=L>25==V  4>78  50  <3/:3  01>  28IV A;V4 22>48B8 H;OE>< V=DC7VW
   ?@>BO3>< ?@8=09<=V 30 E2.

   !;V4  C=8:0B8  ?@87=0G5==O  4>7,  28I8E  70  80 <3/:3 <0A8 BV;0, G5@57
   ?V428I5==O @878:C  28=8:=5==O ?@5F8?VB0BV2.

   %2>@V ;VB=L>3> 2V:C

   %2>@8<  ;VB=L>3>  2V:C :>@5:FVO 4>78 =5 ?>B@V1=0, O:I> DC=:FVO ?5GV=:8
   B0 =8@>: 70;8H0TBLAO =>@<0;L=>N.


   "@820;VABL ;V:C20==O

   "@820;VABL  ;V:C20==O  70;568BL  2V4 ?5@51V3C E2>@>18. /: ?@89=OB> ?@8
   B5@0?VW  0=B81V>B8:0<8,  E2>@8< A;V4 ?@>4>26C20B8 ?@89<0B8 F5DB@80:A>=
   I5  ?@>BO3><  O:  48= ?VA;O B>3>, O: B5@<0;V7CTBLAO V 0=0;V78 ?>:06CBL
   2V4ACB=VABL 71C4=8:V2.

   ><1V=>20=0 B5@0?VO

   >A;V465==O  ?>:070;8,  I>  2V4=>A=>  1030BL>E  3@0<=530B82=8E 10:B5@V9
   VA=CT  A8=5@3V7<  =><   V 03;V:>7840<8.  572060NG8 =0 B5, I> ?V428I5=C
   5D5:B82=VABL  B0:8E  :><1V=0FV9  =5  702648 <>6=0 ?5@5410G8B8, WW A;V4
   <0B8  =0  C207V  ?@8 =0O2=>ABV BO6:8E, 703@>7;828E 4;O 68BBO V=D5:FV9,
   A?@8G8=5=8E   Pseudomonas   aeruginosa.   '5@57   DV78G=C   =5AC=C  B0
   03;V:>784V2 WE A;V4 22>48B8 >:@5<> 2 @5:><5=4>20=8E 4>70E.

   >7C20==O 2 >A>1;828E 28?04:0E

   5=V=3VB

   @8  10:B5@V0;L=>2;OB  V  4VB59 2V:>< 2V4 15 4=V2 4> 12 @>:V2 ;V:C20==O
   @>7?>G8=0NBL  7  4>78  100 <3/:3 (0;5 =5 1V;LH5 4 3) 1 @07 =0 4>1C. /:
   BV;L:8 71C4=8: 1C45 V45=B8DV:>20=89, 0 9>3> GCB;82VABL 287=0G5=0, 4>7C
   <>6=0  2V4?>2V4=>  7=878B8.  09:@0IV  @57C;LB0B8  4>AO30;8AO ?@8 B0:V9
   B@820;>ABV ;V:C20==O:


Neisseria meningitidis

                                                                               4 4=V

                        Haemophilus influenzae

                                                                               6 4=V2

                       Streptococcus pneumoniae

                                                                               7 4=V2


   >@5;V>7 09<0

   >@>A;8<  B0  4VBO<  50  <3/:3  (=0928I0 4>1>20 4>70 2 3) 1 @07 =0 4>1C
   ?@>BO3>< 14 4=V2.

   >=>@5O (3>AB@0 =5CA:;04=5=0)

   ;O   ;V:C20==O   3>=>@5W   (A?@8G8=5=>W  CB2>@NNG8<8  V  =5CB2>@NNG8<8
   ?5=VF8;V=07C  HB0<0<8)  @5:><5=4CTBLAO  ?@87=0G0B8  @07>2C 4>7C 250 <3
   2=CB@VH=L>2>.

   @>DV;0:B8:0 V=D5:FV9 C EV@C@3VW

   ;O  ?@>DV;0:B8:8  ?VA;O>?5@0FV9=8E  V=D5:FV9 C EV@C@3VW @5:><5=4CTBLAO
   (70;56=>  2V4  ABC?5=O  =5157?5:8  70@065==O) 22>48B8 @07>2C 4>7C 12 3
   F5DB@80:A>=C  2=CB@VH=L>2>  01>  C  283;O4V ?>2V;L=>W 2=CB@VH=L>25==>W
   V=T:FVW 70 3090 E28;8= 4> ?>G0B:C >?5@0FVW. @8 >?5@0FVOE =0 B>2ABV9 B0
   ?@O1@5  70@5:><5=4C20;>  A515  >4=>G0A=5  (0;5  >:@5<5)  22545==O  2 3
   ?@5?0@0BC V >4=>3> 7 5-=VB@>V;V2.

   8@:>20 01> ?5GV=:>20 =54>AB0B=VABL

   %2>@8< V7 ?>@CH5==O<8 DC=:FVW =8@>: =5<0T =5>1EV4=>ABV 7=86C20B8 4>7C,
   O:I> DC=:FVO ?5GV=:8 70;8H0TBLAO =>@<0;L=>N.

   8H5  C  @07V  =8@:>2>W  =54>AB0B=>ABV  2  ?5@54B5@1>20 4>70 =5 ?>28==0
   ?5@528IC20B8 2 3.

   %2>@8<  V7  ?>@CH5==O<8  DC=:FVW  ?5GV=:8 =5<0T =5>1EV4=>ABV 7=86C20B8
   4>7C, O:I> DC=:FVO =8@>: 70;8H0TBLAO =>@<0;L=>N.

   @8   >4=>G0A=V9  BO6:V9  =8@:>2V9  B0  ?5GV=:>2V9  =54>AB0B=>ABV  A;V4
   @53C;O@=>  287=0G0B8  :>=F5=B@0FVN  F5DB@80:A>=C C ?;072V B0 ?@>2>48B8
   :>@5:FVN 4>78 ?@5?0@0BC C @07V =5>1EV4=>ABV.

   %2>@8<,    O:V   ?5@51C20NBL   =0   35<>4V0;V7V,   =5<0T   ?>B@518   2
   4>40B:>2>=B@>;N20B8  :>=F5=B@0FVN  F5DB@80:A>=C 2 A8@>20BFV :@>2V I>4>
   <>6;82>W  :>@5:FVW  4>78,  >A:V;L:8  C  F8E  E2>@8E  <>65  7=86C20B8AO
   H284:VABL 282545==O. >1>20 4>70 =5 ?>28==0 ?5@528IC20B8 2 3.

   @83>BC20==O @>7G8=V2

   >BC20B8 @>7G8=8 157?>A5@54=L> ?5@54 WE 70AB>AC20==O<.

   !2V6>?@83>B>2;5=V  @>7G8=8  715@V30NBL  A2>N DV78G=C V EVBO3>< 6 3>48=
   ?@8 :V<=0B=V9 B5 ?@>BO3>< 24 3>48= ?@8 B5°
   !).   15@V30B8  @>7G8=8  2  70E8I5=>  2V4  :>=F5=B@0FVW  V  B@820;>ABV
   715@V30==O   :>;V@   @>7G8=V2  <>65  20@VN20B8  2V4  1;V4>-6>2B>3>  4>
   1C@HB8=>2>3>.   &O   2;0AB82VABL   0:B82=>W  @5G>28=8  =5  2?;820T  =0
   5D5:B82=VABL 01> ?5@5=>A8

   =CB@VH=L>20 V=T:FVO

   ;O  2=CB@VH=L>2>W  V=T:FVW  250  <3 F5DB@80:A>=C @>7G8=ONBL C 1 <; 1 %
   @>7G8=C  ;V4>:0W=C,  0  1 3 @>7G8=ONBL C 3,5 <; 1 % @>7G8=C ;V4>:0W=C;
   V=T:FVN @>1;OBL 3;81>:> C AV4=8G=89 = =5 A;V4 74=>

   5:><5=4CTBLAO  22>48B8  =5  1V;LH5  1  3 2 >4=C AV4=8FN. 5@54 V=T:FVTN
   ?@>25AB8 H:V@=C ?@>1C =0 GCB;82VABL 4> ;V4>:0W=C.

   >7G8=, I> :0W=, =5 <>6=0 22>48B8 2=CB@VH=L>25==>.

   =CB@VH=L>25==0 V=T:FVO

   ;O  2=CB@VH=L>25==>W  V=T:FVW  @>7G8=ONBL  250  <3 F5DB@80:A>=C 2 5 <;
   AB5@8;L=>W  2>48  4;O  V=T:FV9,  0   1   3   F5DB@80:A>=C    2  10  <;
   AB5@8;L=>W  2>48  4;O V=T:FV9; 22>4OBL 2=CB@VH=L>25==> ?>2V;L=>

   (2-4 E2).

   =CB@VH=L>25==5  2;820==O

   =CB@VH=L>25==5   2;820==O   ?>28==>   B@820B8   =5  <5=H5  30  E2.  ;O
   ?@83>BC20==O  @>7G8=C  4;O  2;820==O  @>7G8=ONBL  2  3 ;2>10:C 2 40 <;
   >4=>3>  7  B0:8E V=DC7V9=8E @>7G8=V2, 2V;L=8E 2V4 V>=V2 :0;LFVN: 0,9 %
   E;>@84 =0B@VN, 0,45 % E;>@84 =0B@VN + 2,5 % 3;N:>70, 5 % 3;N:>70, 10 %
   3;N:>70,   6   %   45:AB@0=   C   @>7G8=V   3;N:>78   5   %,   6-10  %
   3V4@>:AV5B8;L>20=89  :@>E<0;L. 250 <3 F5DB@80:A>=C 709<0NBL >1T< 0,194
   <;.  2060NG8 =0 <>6;82C =5AC7G8=8, O:V =, =5 <>6=0 77G8=0<8, O:V B8:8,
   O: ?@8 ?@83>BC20==V, B0: V ?@8 22545==V.

   0;8H:8 ?@5?0@0BC A;V4 28:8=CB8.

   4=0:  2  3  F5DB@80:A>=C  B0  1 3 >@=V407>;C DV78G=> B0 EV AC;>3VG=>3>
   @>7G8=C =0B@VN E;>@84C 01> @>7G8=C 3;N:>78.

   5 <>6=0 28:>@8AB>2C20B8 @>7G8==8:8, O:V 7G8= V=35@0 G8 @>7G8= 0@B<0=0,
   4;O  @>7G8=5==O  ;2>10:C  C  D;0:>=0E  G8  4;O @>72545==O 2V4=>2;5=>3>
   @>7G8=C   4;O  2=CB@VH=L>25==>3>  22545==O  C  72O7:C  7  2V@>3V4=VABN
   CB2>@5==O   ?@5F8?VB0BV2   :0;LFVT28E  A>;59  F5DB@80:A>=C.  8=8:=5==O
   ?@5F8?VB0BV2  :0;LFVT28E A>;59 F5DB@80:A>=C B0:>6 <>65 2V41C20B8AO ?@8
   710:C  7  @>7G8=0<8, O:V 4=V9 V=DC7V9=V9 A8AB525==>3> 22545==O. ;2>10:
   =5   <>6=0  >4=>G0A=>  22>48B8  2=CB@VH=L>25==>  7  @>7G8=0<8,  O:V  <
   =>2>=0@>465=8E,  ;2>10:^  B0  :0;LFVT27G8=8  <>6=0 22>48B8 ?>A;V4>2=>,
   O:I>   V=DC7V9=C   A8AB5  ?@><8B8  7G8=><  (482.  «70T<>4VO  7  V=H8<8
   ;V:0@AL:8<8 70A>10<8 B0 V=HV 2848 270T<>4V9»).


   >1VG=V @50:FVW.

   0728G09  F5DB@80:A>=  ?5@5=>A8BLAO 4>1@5. @8 9>3> 70AB>AC20==V <>6;82V
   =86G5707=0G5=V ?>1VG=V O28I0, O:V @53@5AC20;8 A?>=B0==> 01> ?VA;O 2V4

   51060=8<8  @50:FVO<8,  I>  =09G0ABVH5  A?>AB5@V30;8AO ?@8 70AB>AC20==V
   F5DB@80:A>=C,  T  5>78=>DV;VO,  ;59:>?5=VO,  B@><1>F8B>?5=VO,  4V0@5O,
   28A8? B0 ?V428I5==O @V2=O ?5GV=:>28E D5@<5=BV2.

   '0AB>BC  28=8:=5==O  =51060=8E  @50:FV9  =0  F5DB@80:A>=  287=0G0;8 70
   40=8<8 :;V=VG=8E 4>A;V465=L.

   0 G0AB>B>N O28I0 :;0A8DV:>20=V B0:8< G8=>

   C65 ?>H8@5=V         (? 1/10)

   >H8@5=V                  (? 1/100 < 1/10)

   5?>H8@5=V              (? 1/1000 < 1/100)

   V4:> ?>H8@5=V         (? 1/10000 < 1/1000)

   '0AB>B0  =52V4><0  (=5<>6;82>  >FV=8B8  70  =0O2=8<8 40=8<8; 70 40=8<8
   ?>AB<0@:5B8=3>28E  ?>2V4><;5=L.  A:V;L:8  ?>2V4><;5==O  ?@> FV @50:FVW
   1C;8  4>1@>2V;L=8<8  V  @>7?C;OFVW  =52V4><89, =04V9=> >FV=8B8 G0AB>BC
   O28I   =5<>6;82>,   B>=8  2V4=5A5=V  4>  :0B53>@VW  @50:FV9  =52V4><>W
   G0AB>B8.)

   =D5:FVW  B0  V=207VW:  ?>H8@5=V:  7 AB0B528E H;OEV2, 2B>@8==V 3@81:>2V
   V=D5:FVW    B0   V=D5:FVW,   A?@8G8=5=V   @578AB5=B=8<8   >@30=V7<0<8;
   =5?>H8@5=V:   3@81:>2V  V=D5:FVW  AB0B528E  >@30=V2;  @V4:>  ?>H8@5=V:
   ?A524><5<1@0==89 :>;VB; G0AB>B0 =52V4><0: AC?5@V=D5:FVW.

   1>:C  A8AB5<8 :@>2V B0 ;VW A8AB5<8: ?>H8@5=V: 5>78=>DV;VO, ;59:>?5=VO,
   B@><1>F8B>?5=VO,  =5?>H8@5=V:  3@0=C;>F8B>?5=VO,  0=57;048 :>03C;OFVW;
   G0AB>B0  =52V4><0:  35<>;VB8G=0  0=5F8B>7,  71V;LH5==O ?@>B@><1V=>2>3>
   G0AC,  ?V428I5==O  @V2=O  :@50B8=V=C  2  A8@>20BFV  :@>2V,  C65  @V4:>
   A?>AB5@V30;8AO  28?04:8  03@0=C;>F8B>7C  (< 500/<<^3), ?5@5206=> ?VA;O
   70AB>AC20==O 7030;L=>W 4>78 20 3 G8 1V;LH5. V4 G0A B@820;>3> ;V:C20==O
   A;V4  @53C;O@=>  :>=B@>;N20B8 :0@B8=C :@>2V. >2V4><;O;>AO ?@> =57=0G=5
   ?>4>265==O ?@>B@><1V=>2>3> G0AC.

   1>:C  VW  A8AB5<8: G0AB>B0 =52V4><0: 0=0DV;0:B8G=89 H>:, 0=0DV;0:B8G=V
   @50:FVW, 0=0DV;0:B>W4=V @50:FVW, 3V?5@GCB;82VABL.

   1>:C  =5@2>2>W  A8AB5<8:  =5?>H8@5=V:  3>;>2=89  1V;L,  70?0<>@>G5==O;
   G0AB>B0 =52V4><0: AC4><8.

   1>:C >@30=V2 A;CEC V @V2=>2038: G0AB>B0 =52V4><0: 25@BV3>.

   1>:C  >@30=V2 48E0==O, 3@C4=>W :;VB:8 B0 A5@54>ABV==O: @V4:> ?>H8@5=V:
   1@>=E>A?07<.

   1>:C  B@02=>3>  B@0:BC:  4V0@5O;  =C4>B0;  1;N20==O; AB><0B8B; 3;>A8B;
   ?0=:@50B8B, I> @>728=C2AO, <>6;82>, 2=0A;V4>: >1AB@C:FVW 6>2G>282V4=8E
   H;OEV2.   V;LHVABL   V7  F8E  E2>@8E  <0;8  D0:B>@8  @878:C  70AB>N  C
   6>2G>282V4=8E   H;OE0E,   =0?@8:;04   ;V:C20==O   2   0=0<=57V,  BO6:V
   70E2>@N20==O B0 ?>2=VABN ?0@5=B5@0;L=5 E0@GC20==O. @8 FL>6=0 28:;NG0B8
   @>;L  ?@5F8?VB0BV2  C  @>728B:C  ?0=:@50B8BC,  I>  CB2>@8;8AO ?V4 4VTN
   F5DB@80:A>=C    2    6>2G>282V4=8E   H;OE0E;   4C65   @V4:>   ?>H8@5=V
   ?A524><5<1@0=>7=89 5=B5@>:>;VB.

   1>:C 35?0B>1V;V0@=>W A8AB5<8: ?@5F8?VB0B8 :0;LFVT2>W A>;V F5DB@80:A>=C
   C  6>2G=>2V4=>N  A8<0B8:>N  C  4VB59,  >1>@>B=89  E>;5;VBV07  C  4VB59
   (2:070=V   O28I0  @V4:>  A?>AB5@V30;8AL  C  4VB59),  71V;LH5==O  @V2=O
   ?5GV=:>28E D5@<5=BV2 C A8@>20BFV :@>2V (!", ", ;C6=>W D>AD0B078).

   1>:C  H:V@8  V  ?V4H:V@=>W  :;VB:>28=8:  ?>H8@5=V:  28A8?; =5?>H8@5=V:
   A25@1V6;   @V4:>   ?>H8@5=V:  :@>?82O=:0;  G0AB>B0  =52V4><0:  A8=4@><
   !BV25=A0-6>=A>=0,  B>:A8G=89  5?V45@<0;L=89 =5:@>;V7 (A8=4@>< 09T;;0),
   1030B>D>@<=0    5@8B5<0,   3>AB@89   35=5@0;V7>20=89   5:70=B5<0B>7=89
   ?CABC;L>7.

   1>:C  A5G>284V;L=>W  A8AB5<8:  @V4:>  ?>H8@5=V: 35<0BC@VO, 3;N:>7C@VO;
   G0AB>B0  =52V4><0: >;V3C@VO, CB2>@5==O :>=:@5<5=BV2 C =8@:0E, 3>;>2=8<
   G8=><  C  4VB59  2V:><  2V4 3 @>:V2, O:V >B@81>2V 4>78 ?@5?0@0BC (? 80
   <3/:3 =0 4>1C) 01> :C78 ?>=04 10 3, 0 B0:>6 O:V <0;8 4>40B:>2V D0:B>@8
   @878:C   (>1<565=5   26820==O  @V48=8,  ?>ABV;L=89  @568<).  #B2>@5==O
   :>=:@5<5=BV2  C  =8@:0E  <>65  <0B8  157A8<=89 ?5@51V3 01> ?@>O2;OB8AO
   :;V=VG=>,  <>65  A?@8G8=8B8  =8@:>2C  =54>AB0B=VABL,  O:0  <8=0T ?VA;O
   ?@8?8=5==O ;V:C20==O F5DB@80:A>=><.

   030;L=V  @>7;048:  =5?>H8@5=V: 3>;>2=89 1V;L V 70?0<>@>G5==O, 30@OG:0,
   0=0DV;0:B8G=V  01>  0=0DV;0:B>W4=V  @50:FVW;  @V4:>  ?>H8@5=V: =01@O:,
   >7=>1.

   #  ?>>48=>:8E 28?04:0E A?>AB5@V30NBLAO 70?0;L=V @50:FVW ABV=:8 25=8. E
   <>6=0 C=8:=CB8, 70AB>A>2CNG8 ?>2V;L=C V=T:FVN (2-4 E2).

   =CB@VH=L>20 V=T:FVO 157 70AB>AC20==O ;V4>:0W=C 1>;NG0.

   70T<>4VO 7 :0;LFVT<

   &5DB@80:A>=  =5  <>6=0  ?@87=0G0B8  >4=>G0A=>  G8 77G8=0<8, =02VBL ?@8
   70AB>AC20==V  >:@5<8E  V=DC7V9=8E  A8AB5<.  ?8A0=0  =525;8:0 :V;L:VABL
   ;5B0;L=8E  28?04:V2  2=0A;V4>: CB2>@5==O ?@5F8?VB0BV2 :0;LFVT28E A>;59
   F5DB@80:A>=C  C  ;535=OE  B0  =8@:0E =>2>=0@>465=8E. # 45O:8E 28?04:0E
   25=>7=V  4>ABC?8  B0  G0A 22545==O F5DB@80:A>=C B0 :0;LFVT27G8=V2 1C;8
   @V7=V.

   C;8  ?@>2545=V  2  4>A;V465==O  in  vitro,  C O:8E 282G0;0AL 270T<>4VO
   F5DB@80:A>=C  B0  :0;LFVN  (>4=5  4>A;V465==O  V7 70AB>AC20==O< ?;07<8
   :@>2V   4>@>A;8E,  V=H5  V7  70AB>AC20==O<  ?;07<8  :@>2V  7  ?C?>28=8
   =>2>=0@>465=8E).  &5DB@80:A>=  C  :>=F5=B@0FVW  4>  1  <  (C  =04;8H:C
   :>=F5=B@0FVW  4>AO30;8AL  in  vivo  ?VA;O  2=CB@VH=L>25==>3>  2;820==O
   ?@>BO3><  30  E28;8=  2 3 F5DB@80:A>=C) 70AB>A>2C20;8AO C :><1V=0FVW 7
   :0;LFVT<  C :>=F5=B@0FVW 4> 12 < (48 <3/4;). V4=>2;5==O F5DB@80:A>=C 7
   ?;07<8  :@>2V  7<5=HC20;>AO ?@8 :>=F5=B@0FVW :0;LFVN 6 < (24 <3/4;) G8
   28I5   C  ?;072V  4>@>A;8E  B0  4  <  (16  <3/4;)  G8  28I5  C  ?;072V
   =>2>=0@>465=8E.  &5 <>65 2V4>1@060B8 CB2>@5==O ?@5F8?VB0BV2 :0;LFVT28E
   A>;59 F5DB@80:A>=C.

   ?;82 =0 @57C;LB0B8 ;01>@0B>@=8E 0=0;V7V2

   #  ?>>48=>:8E  28?04:0E  ?@8  ;V:C20==V  F5DB@80:A>=>< C E2>@8E <>6CBL
   2V47=0G0B8AO   E81=>?>78B82=V   @57C;LB0B8  B5ABC  C<1A0.  /:  V  V=HV
   0=B81V>B8:8,  F5DB@80:A>=  <>65  A?@8G8=OB8  E81=>?>78B82=89 @57C;LB0B
   ?@>18  =0  30;0:B>75?>78B82=V  @57C;LB0B8  <>6CBL  1CB8 >B@8<0=V V ?@8
   287=0G5==V  3;N:>78  2  A5GV, B>=>< 3;N:>7C@VN, ?@8 =5>1EV4=>ABV, A;V4
   287=0G0B8 ;8H5 D5@<5=B=8< <5B>4><.

   =D5:FV B0 V=207VW.

   8?04:8  4V0@5W ?VA;O 70AB>AC20==O F5DB@80:A>=C <>6CBL 1CB8 ?>2O70=V V7
   Clostridium  difficile. !;V4 ?@87=0G8B8 2V4?>2V4=C :V;L:VABL @V48=8 B0
   5;5:B@>;VBV2 (482. @>74V; «A>1;82>ABV 70AB>AC20==O»).



   @5F8?VB0B8 :0;LFVT2>W A>;V F5DB@80:A>=C.

   V4:VA=V   28?04:8   BO6:8E  =51060=8E  @50:FV9,  V=>4V  V7  ;5B0;L=8<8
   =0A;V4:0<8,  70@5TAB@>20=V  C  =54>=>H5=8E B0 4>=>H5=8E =>2>=0@>465=8E
   (2V:><  <  28  4=V2),  O:8<  2=CB@VH=L>25==>  22>48;8  F5DB@80:A>=  B0
   ?@5?0@0B8  :0;LFVN.  @8  0CB>?AVW  C  ;535=OE  B0 =8@:0E 1C;8 28O2;5=V
   ?@5F8?VB0B8  :0;LFVT2>W  A>;V  F5DB@80:A>=C.  8A>:89  @878:  CB2>@5==O
   ?@5F8?VB0BV2  C =>2>=0@>465=8E T =0A;V4:>< WE <0;>3> >1T2V B0 4>2H>3>,
   =V6  C  4>@>A;8E,  ?5@V>4C  =0?V2282545==O  F5DB@80:A>=C (482. @>74V;8
   «@>B8?>:070==O», «A>1;82>ABV 70AB>AC20==O»).

   0@5TAB@>20=V  28?04:8  CB2>@5==O  ?@5F8?VB0BV2  C  =8@:0E, ?5@5206=> C
   4VB59 2V:>< 2V4 3 @>:V2, O:V >B@8
   25;8:V   4>1>2V   4>78  ?@5?0@0BC  (=0?@8:;04  ?  80  <3/:3/4>1C)  01>
   7030;L=V 4>78 ?>=04

   10  3@06  <0;8 4>40B:>2V D0:B>@8 @878:C (=0?@8:;04 >1<565=5 A?>6820==O
   @V48=8  01>  ?>ABV;L=89  @568<). 878: CB2>@5==O ?@5F8?VB0BV2 7@>AB0T C
   ?0FVT=BV2,  ?>7102;5=8E  @CE;82>ABV  01> C E2>@8E C AB0=V 7=52>4=5==O.
   @5F8?VB0B8  <>6CBL  AC?@>2>46C20B8AO  A8<0<8  01>  1CB8  0A8<0B8G=8<8,
   <>6CBL  ?@872>48B8  4>  =8@:>2>W  =54>AB0B=>ABV  B0 0=C@VW, V 7=8:0NBL
   ?VA;O  ?@8?8=5==O  70AB>AC20==O  F5DB@80:A>=C (482. @>74V; «A>1;82>ABV
   70AB>AC20==O»).

   0@5TAB@>20=V    28?04:8   CB2>@5==O   ?@5F8?VB0BV2   :0;LFVT2>W   A>;V
   F5DB@80:A>=C  C  6>2G=>  C  ?0FVT=BV2,  O:8< ?@5?0@0B 22>48;8 C 4>70E,
   28I8E 70 AB0=40@B=C @5:><5=4>20=C 4>7C.

   #   4VB59,  70  40=8<8  ?@>A?5:B82=8E  4>A;V465=L,  G0AB>B0  CB2>@5==O
   ?@5F8?VB0BV2 ?@8 2=CB@VH=L>25==>N C 45O:8E 4>A;V465==OE ?>=04 30 %. @8
   ?>2V;L=>BO3><  20-30 E28;8=) G0AB>B0 CB2>@5==O ?@5F8?VB0BV2, >G5284=>,
   =86G0.  #B2>@5==O ?@5F8?VB0BV2 70728G09 =5 AC?@>2>46CTBLAO A8<0<8, 0;5
   C  @V4:VA=8E  28?04:0E  28=8:0;8  B0:V :;V=VG=V A8<8 O: 1V;L, =C4>B0 V
   1;N20==O.  B0:8E  28?04:0E  @5:><5=4CTBLAO  A8<0B8G=5  ;V:C20==O. VA;O
   ?@8?8=5==O  70AB>AC20==O  F5DB@80:A>=C  ?@5F8?VB0B8  70728G09 7=8:0NBL
   (482. @>74V; «A>1;82>ABV 70AB>AC20==O»).


   5@54>7C20==O.

   #  @07V  ?5@54>7C20==O 35<>4V0;V7 G8 ?5@8B>=50;L=89 4V0;V7 =5 7<5=H0BL
   :>=F5=B@0FVW   ?@5?0@0BC   2   ?;072V.   #   @07V  ?5@54>7C20==O  <>65
   A?>AB5@V30B8AO  =C4>B0,  1;N2>B0,  4V0@5O.  !?5F8DVG=>3>  0=B84>BC  =5
   VA=CT. V:C20==O ?5@54>7C20==O A8<0B8G=5.


   0AB>AC20==O C ?5@V>4 203VB=>ABV 01> 3>4C20==O 3@C44N.

   03VB=VABL.

   &5DB@80:A>=  ?@>=8:0T  G5@57  ?;0F5=B0@=89 10@T@. A=CNBL >1<565=V 40=V
   I>4> 70AB>AC20==O F5DB@80:A>=C 203VB=8< 6V=:0<. >A;V465==O =0 B20@8=0E
   =5  A2V4G0BL  ?@> 157?>A5@54=V9 01> >?>A5@54:>20=89 H:V4;8289 2?;82 =0
   5<1@V>=/?;V4,  ?5@8-  B0  ?>AB=0B0;L=89  @>728B>:.  V4 G0A 203VB=>ABV,
   7>:@5<0  C  ?5@H>=  <>6=0  70AB>A>2C20B8,  ;8H5 O:I> :>@8ABL ?5@528ICT
   @878:.

   >4C20==O 3@C44N.

   &5DB@80:A>=  ?@>=8:0T C 3@C4=5 <>;>:> C =87L:8E :>=F5=B@0FVOE, 0;5 ?@8
   70AB>AC20==V  ?@5?0@0BC  C  B5@0?52B8G=8E  4>70E =5 >GV:CTBLAO 6>4=>3>
   2?;82C  =0  3@C4=8E  =5<>2;OB.  @>B5 =5 <>6=0 28:;NG0B8 @878: @>728B:C
   4V0@5W  B0  3@81:>2>W  V=D5:FVW  A;87>28E  >1>;>=>:.  !;V4 2@0E>2C20B8
   <>6;82VABL  A5=A81V;V70FVW.  >B@V1=>  ?@89=OB8 @VH5==O I>4> ?@8?8=5==O
   3>4C20==O  3@C44N 01> ?@8?8=5==O/2V4<>28 2V4 70AB>AC20==O F5DB@80:A>=C
   V7  2@0EC20==O<  :>@8ABV  2V4  3@C4=>3>  283>4>2C20==O  4;O  48B8=8 B0
   :>@8ABV 2V4 B5@0?VW 4;O 6V=:8.

   $5@B8;L=VABL.

   #   4>A;V465==OE   @5?@>4C:B82=>W   DC=:FVW  =5  1C;>  28O2;5=>  >7=0:
   =51060=>3> 2?;82C =0 G>;>2VGC 01> 6V=>GC D5@B8;L=VABL.


   VB8.

   @5?0@0B  70AB>A>2CNBL  4VBO<  73V4=>  7 4>7C20==O<, 2:070=8< C @>74V;V
   «!?>AV1 70AB>AC20==O B0 4>78».


   A>1;82>ABV 70AB>AC20==O.

   50:FVW 3V?5@GCB;82>ABV.

   /:  V ?@8 70AB>AC20==V 2AVE 15B0-;0:B0<=8E 0=B81V>B8:V2, ?>2V4><;O;>AO
   ?@>  28?04:8  A5@9>7=8E  @50:FV9  3V?5@GCB;82>ABV, V=>4V V7 ;5B0;L=8<8
   =0A;V4:0<8  (482.  @>74V;  «>1VG=V @50:FVW»). # 28?04:C BO6:8E @50:FV9
   3V?5@GCB;82>ABV  70AB>AC20==O  F5DB@80:A>=C  A;V4 =5309=> ?@8?8=8B8 B0
   268B8  =0;56=8E  =52V4:;04=8E  70E>4V2.  5@54  ?>G0B:>< ;V:C20==O A;V4
   2AB0=>28B8,  G8  T C ?0FVT=B0 2 0=0<=57V BO6:V @50:FVW 3V?5@GCB;82>ABV
   4>  F5DB@80:A>=C,  V=H8E F5D0;>A?>@8=V2 01> V=H8E B8?V2 15B0-;0:B0<=8E
   70A>1V2.  !;V4  7  >15@56=VABN  70AB>A>2C20B8 F5DB@80:A>= ?0FVT=B0< V7
   =0O2=VABN  2 0=0<=57V =5BO6:>W 3V?5@GCB;82>ABV 4> V=H8E 15B0-;0:B0<=8E
   ?@5?0@0BV2.

   0@5TAB@>20=V  28?04:8  BO6:8E  =51060=8E @50:FV9 7 1>:C H:V@8 (A8=4@><
   !BV25=A0-6>=A>=0  01> A8=4@>< 09T;0/B>:A8G=89 5?V45@<0;L=89 =5:@>;V7);
   >4=0: G0AB>B0 F8E O28I =52V4><0 (482. @>74V; «>1VG=V @50:FVW»).

   70T<>4VO V7 ;V:0@AL:8<8 70A>10<8, I>

   #  =54>=>H5=8E  B0  4>=>H5=8E  =5<>2;OB  2V:><  <5=H5 1 ?8A0=V 28?04:8
   CB2>@5==O  ?@5F8?VB0BV2  :0;LFVT2>W  A>;V  F5DB@80:A>=C  C  ;535=OE B0
   =8@:0E V7 ;5B0;L=8<8 =0A;V4:0<8. )>=09<5=H5 >4=>= B0 :0;LFV9 22>48;8 C
   @V7=89  G0A B0 G5@57 @V7=V 2=CB@VH=L>25==V V=DC7V9=V A8AB5<8. 3V4=> V7
   =0O2=8<8  =0C:>28<8  40=8<8,  =5  70@5TAB@>20=> ?V4B25@465=8E 28?04:V2
   CB2>@5==O  2=CB@VH=L>AC48==8E  ?@5F8?VB0BV2, :@V< O: C =>2>=0@>465=8E,
   O:8<   22>48;8   F5DB@80:A>=   B0   :0;LFVT27G8=8  01>  1C4L-O:V  V=HV
   :0;LFVT2A;V465==OE  Vn vitro 1C;> ?>:070=>, I> =>2>=0@>465=8< 703@>6CT
   ?V428I5=89  @878:  CB2>@5==O ?@5F8?VB0BV2 :0;LFVT2>W A>;V F5DB@80:A>=C
   ?>@V2=O=> V7 ?0FVT=B0<8 V=H8E 2V:>28E 3@C?.

   @8  70AB>AC20==V  F5DB@80:A>=C  ?0FVT=B0<  1C4L-O:>3> 2V:C ?@5?0@0B =5
   <>6=0    7    22>48B8    >4=>G0A=>   V7   1C4L-O:8<8   @>7G8=0<8   4;O
   2=CB@VH=L>25==>3>  22545==O,  I> @8AB0==V @V7=8E V=DC7V9=8E A8AB5< 01>
   22545==V  ?@5?0@0BV2  C  @V7=V V=DC7V9=V 4V;O=:8. @>B5 ?0FVT=B0< 2V:><
   AB0@H5  28 4=V2 F5DB@80:A>= B0 :0;LFVT27G8=8 <>6=0 22>48B8 ?>A;V4>2=>,
   >48=  ?VA;O >4=>3>, 70 C<>28 22545==O ?@5?0@0BV2 G5@57 @V7=V V=DC7V9=V
   A8AB5<8  C  @V7=V  4V;O=:8 BV;0 01> 703> ?@><820==O V=DC7V9=>W A8AB5<8
   1V2   DV7V>;>3VG=8<   A>;L>28<   @>7G8=><,   I>1  70?>1V3B8  CB2>@5==N
   ?@5F8?VB0BC. 0FVT=B0<, O:V ?>B@51CNBL ?>ABV9=8E V=DC7V9 :0;LFVT27G8=V2
   4;O  ?>2=>3> ?0@5=B5@0;L=>3> E0@GC20==O (%), <548G=V ?@0FV2=8:8 <>6CBL
   ?@87=0G8B8 0;LB5@=0B82=V 0=B810:B5@V0;L=V 70A>18, 70AB>AC20==O O:8E =5
   ?>2O70=5 V7 ?>4V1=8< @878:>< CB2>@5==O ?@5F8?VB0BV2. /:I> 70AB>AC20==O
   F5DB@80:A>=C  ?0FVT=B0<, O:V ?>B@51CNBL ?>ABV9=>3> E0@GC20==O, 287=0=>
   =5>1EV4=8<, @>7G8=8 4;O % B0 F5DB@80:A>= <>6=0 22>48B8 >4=>G0A=>, E>G0
   V  G5@57  @V7=V  V=DC7V9=V  A8AB5<8  B0  C  @V7=V  4V;O=:8 BV;0. "0:>6
   22545==O  @>7G8=V2 4;O % <>6=0 ?@87C?8=8B8 =0 G0A V=DC7VW F5DB@80:A>=C
   B0  ?@><8B8  V=DC7V9=V  A8AB5<8  7G8=V2 (482. @>74V;8 «@>B8?>:070==O»,
   «>1VG=V @50:FVW» B0 «5AC

   VB8.

   57?5:0  B0  5D5:B82=VABL  ;2>10:C  C =>2>=0@>465=8E, =5<>2;OB B0 4VB59
   1C;8  2AB0=>2;5=V  4;O 4>7, >?8A0=8E C @>74V;V «!?>AV1 70AB>AC20==O B0
   4>78».  #  4>A;V465==OE  1C;>  ?>:070=>, I> F5DB@80:A>=, O: 45O:V V=HV
   F5D0;>A?>@8=8,  <>65 28BVA=OB8 1V;V@C1V= 7V 72O7:C V7 0;L1C< A8@>20B:8
   :@>2V.

   ;2>10:  ?@>B8?>:070=89  =54>=>H5=8<  B0 4>=>H5=8< =>2>=0@>465=8<, O:8<
   703@>6CT  @878:  @>728B:C  1V;V@C1V=>2>W  5=F5D0;>?0BVW  (482.  @>74V;
   «@>B8?>:070==O»).

   >?>A5@54:>20=0 35<>;VB8G=0 0=5

   8?04:8  V>?>A5@54:>20=>W  35<>;VB8G=>W 0=5AB5@V30;8AO C ?0FVT=BV2, O:V
   >B@818  :;0AC  F5D0;>A?>@8=V2, 2 B>10: (482. @>74V; «>1VG=V @50:FVW»).
   "O6:V  28?04:8  35<>;VB8G=>W  0=520=V 2 ?5@V>4 ;V:C20==O ;2>10:>< O: C
   4>@>A;8E, B0: V C 4VB59.

   /:I>  ?V4 G0A 70AB>AC20==O F5DB@80:A>=C C ?0FVT=B0 28=8:0T 0=573;O=CB8
   4V03=>7  0=5FV9>20=>W  V7  70AB>AC20==O<  F5D0;>A?>@8=C,  B0 ?@8?8=8B8
   70AB>AC20==O F5DB@80:A>=C 4> 2AB0=>2;5==O 5BV>;>3VW 70E2>@N20==O.

   >23>B@820;5 ;V:C20==O.

   @8 4>23>B@820;> ?@>2>48B8 @>73>@=CB89 0=0;V7 :@>2V.

   >;VB/=04>@30=V7

   8?04:8   :>;VBC   B0   ?A524><5<1@0=>7=>3>   :>;VBC,  0A>FV9>20=8E  V7
   70AB>AC20==O<  0=B810:B5@V0;L=8E  70A>1V2,  1C;8 70@5TAB@>20=V =0 D>=V
   70AB>AC20==O  <0965  2AVE  0=B810:B5@V0;L=8E 70A>1V2, 2 B>=C. "O6:VABL
   F8E  70E2>@N20=L  <>65 :>;820B8AO 2V4 ;53:>W 4> 703@>7;82>W 4;O 68BBO.
   ">  2@0E>2C20B8 <>6;82VABL B0:>3> 4V03=>7C C ?0FVT=BV2, C O:8E ?V4 G0A
   01>  ?VA;O  70AB>AC20==O  F5DB@80:A>=C  28=8:;0  4V0@5O  (482.  @>74V;
   «>1VG=V  @50:FVW»).  !;V4  >1=><  B0  70AB>AC20==O 2V4?>2V4=8E 70A>1V2
   ?@>B8   Clostridium   difficile.   V:0@AL:V   70A>18,  I>  ?@83=VGCNBL
   ?5@8AB0;LB8:C, 70AB>A>2C20B8 =5 A;V4.

   /: V ?@8 70AB>AC20==V V=H8E 0=B810:B5@V0;L=8E 70A>1V2, <>6CBL 28=8:0B8
   AC?5@V=D5:FVW, A?@8G8=5=V =5GCB;828<8 4> ?@5?0@0BC >@30=V7<0<8.

   "O6:0 =8@:>20 B0 ?5GV=:>20 =54>AB0B=VABL.

   #  28?04:C  BO6:>W =8@:>2>W B0 ?5GV=:>2>W =54>AB0B=>ABV @5:><5=4>20=89
   @5B5;L=89 :;V=VG=89 <>=VB>@8=3 157?5:8 B0 5D5:B82=>ABV ?@5?0@0BC (482.
   @>74V; «!?>AV1 70AB>AC20==O B0 4>78»).

   ?;82 =0 @57C;LB0B8 A5@>;>3VG=8E 4>A;V465=L.

   @8 70AB>AC20==V ?@5?0@0BC ;2>10: B5AB C<1A0 <>65 4020B8 E81=>?>78B82=V
   @57C;LB0B8.  "0:>6  ;2>10:  <>65  A?@8G8=OB8 E81=>?>78B82=V @57C;LB0B8
   0=0;V7C =0 =0O2=VABL 30;0:B>7574V; «>1VG=V @50:FVW»).

   @8  287=0G5==V  3;N:>78  C  A5GV  =5D5@<5=B=8<8  <5B>40<8  <>6CBL 1CB8
   >B@8<0=V E81=>?>78B82=V @57C;LB0B8. @>BO3>< 70AB>AC20==O ;2>10:C @V2=V
   3;N:>78  C A5GV A;V4 287=0G0B8 70 4>?><>3>N D5@<5=B=8E <5B>4V2 0=0;V7C
   (482. @>74V; «>1VG=V @50:FVW»).

   0B@V9.

   >65=  3@0<  ?@5?0@0BC  ;2>10:  ;L  =0B@VN.  &5  A;V4  27OB8  4>  C2038
   ?0FVT=B0<, O:V 4>B@8=B@>;L>20=8< 2< =0B@VN.

   !?5:B@ 0=B810:B5@V0;L=>W 0:B82=>ABV.

   &5DB@80:A>=  <0T  >1<565=89 A?5:B@ 0=B810:B5@V0;L=>W 0:B82=>ABV V <>65
   1CB8  =5?@840B=8<  4;O 70AB>AC20==O 2 O:>ABV <>=>B5@0?VW ?@8 ;V:C20==V
   ?52=8E  B8?V2  V=D5:FVW, :@V< 28?04:V2, :>;8 71C4=8: 265 ?V4B25@465=89
   (482.  @>74V;  ««!?>AV1  70AB>AC20==O  B0  4>78»).  # 28?04:C ?>;V1=8E
   V=D5:FV9,   :>;8   A5@54   ?V4>7@N20=8E  71C4=8:V2  T  @578AB5=B=V  4>
   F5DB@80:A>=C   >@30=V7<8,   A;V4  @>73;O=CB8  70AB>AC20==O  4>40B:>28E
   0=B81V>B8:V2.

   0AB>AC20==O ;V4>:0W=C.

   /:I>  2  O:>ABV  @>7G8==8:0 70AB>A>2CNBL @>7G8= ;V4>:0W=C, F5DB@80:A>=
   <>6=0   22>48B8  ;8H5  2=CB@VH=L>2>.  5@54  22545==O<  ?@5?0@0BC  A;V4
   >1>2O7:>2>   2@0EC20B8   ?@>B8?>:070==O   4>  70AB>AC20==O  ;V4>:0W=C,
   70AB5@565==O B0 V=HC 2V4?>2V4=C V=D>@<0FVN, =02545=C C V=AB@C:FVWW 4;O
   <548G=>3>  70AB>AC20==O ;V4>:0W=C (482. @>74V; «@>B8?>:070==O»). >7G8=
   ;V4>:0W=C C 6>4=>6=0 22>48B8 2=CB@VH=L>25==>.

   >2G=>:0@>10.

   #   28?04:C   =0O2=>ABV   =0  A>=>3@06;82VABL  CB2>@5==O  ?@5F8?VB0BV2
   :0;LFVT2>W   A>;V   F5DB@80:A>=C.  0BV=5==O,  I>  ?><8;:>2>  22060;8AO
   6>2G=8<8   :0<5=O<8,  A?>AB5@V30;8AO  =0  A>=>3@0<0E  6>2G=>3>  B0  WE
   28=8:=5==O  7@>AB0;0  ?@8 70AB>AC20==V F5DB@80:A>=C C 4>7V 1 3/4>1C B0
   28I5.  A>1;82>W  >15@56=>ABV  A;V4  4>B@8AC20==V ?@5?0@0BC 4VBO<. "0:V
   ?@5F8?VB0B8   7=8:0NBL   ?VA;O  ?@8?8=5==O  B5@0?VW  F5DB@80:A>=><.  #
   @V4:VA=8E 28?04:0E CB2>@5==O ?@5F8?VB0BV2 :0;LFVT2>W A>;V F5DB@80:A>=C
   AC?@>2>46C20;>AO  A8<0B8:>N.  0  =0O2=>ABV  A8<5=4CTBLAO :>=A5@20B82=5
   =5EV@C@3VG=5  ;V:C20==O,  V  ;V:0@ <0T ?@89=OB8 @VH5==O ?@> ?@8?8=5==O
   70AB>AC20==O ?@5?0@0BC, A?8@0NG8AL =0 @57C;LB0B8 >FV=:8 :>@8ABV-@878:C
   :>=:@5B=>3> 28?04:C (482. @>74V; «>1VG=V @50:FVW»).

   >2G=89 AB07.

   8?04:8  ?0=:@50B8BC,  <>6;82> A?@8G8=5=V =5?@>EV4=VABN 6>2G=8E H;OEV2,
   1C;8  70@5TAB@>20=V  C  ?0FVT=BV2,  O:V  >B@810:  (482. @>74V; «>1VG=V
   @50:FVW»).  V;LHVABL  V7  B0:8E ?0FVT=BV2 <0;8 D0:B>@8 @878:C @>728B:C
   E>;5AB07C  B0  CB2>@5==O  1V;V0@=>3>  A;046C, B0:V O: ?>?5@54=O 7=0G=0
   B5@0?VO,  BO6:0  E2>@>10  B0  ?>2=5  ?0@5=B5@0;L=5 E0@GC20==O. 5 <>6=0
   28:;NG0B8,  I>  V=VFVNNG8<  01>  4>40B:>28<  D0:B>@><  @>728B:C  FL>3>
   ?>@CH5==O  <>65 1CB8 CB2>@5==O C 6>2G=8E H;OE0E ?@5F8?VB0BV2 2=0A;V4>:
   70AB>AC20==O ?@5?0@0BC ;2>10:.

   8@:>2>:0@>10.

   0@5TAB@>20=V  28?04:8  CB2>@5==O  =8@:>28E  :0<5=V2,  I> 7=8:0;8 ?VA;O
   ?@8?8=5==O 70AB>AC20==O F5DB@80:A>=C (482. @>74V; «>1VG=V @50:FVW»). #
   28?04:C   =0O2=>ABV   A818B8  C;LB@072C:>25  >1AB565==O.  VH5==O  I>4>
   70AB>AC20==O  ?@5?0@0BC  ?0FVT=B0<  V7  =0O2=VABN  2 0=0<=57V =8@:>28E
   :0<5=V2  01>  3V?5@:0;LFVC@VW  ?@89<0T ;V:0@, A?8@0NG8AL =0 @57C;LB0B8
   >FV=:8 :>@8ABV-@878:C :>=:@5B=>3> 28?04:C.

   #B8;V70FVO ;V:0@AL:>3> 70A>1C.

   04E>465==O  ;V:0@AL:>3>  70A>1C  C  7>2=VH=T A5@54>28I5 A;V4 725AB8 4>
   1V30B8  ?>B@0?;O==N  ;V:0@AL:>3>  70A>1C C :0=0;V70FV9=C A8AB5 4><0H=V
   2V4E>48.  C4L-O:89  =528:>@8AB0=89  ;V:0@AL:89  70AV1 ?VA;O 70:V=G5==O
   ;V:C20==O   01>   B5@ABV   A;V4   ?>25@=CB8  2  >@83V=0;L=V9  C?0:>2FV
   ?>AB0G0;L=8:C (;V:0@N 01> D0@<0F52BC) 4;O ?@028;L=>W CB8;V70FVW.

   40B=VABL  2?;820B8  =0 H284:VABL @50:FVW ?@8 :5@C20==V 02B>B@0=A?>@B><
   01> @>1>BV 7 V=H8<8 <5E0=V7<0<8.

   5<0T 40=8E ?@> 2?;82 F5DB@80:A>=C =0 H284:VABL @50:FVW, 0;5 C 72O7:C 7
   <>6;82VABN  28=8:=5==O  70?0<>@>G5==O  F5DB@80:A>=  <>65  2?;820B8  =0
   740B=VABL  :5@C20B8  B@0=A?>@B=8<8 70A>10<8 01> ?@0FN20B8 7V A:;04=8<8
   <5E0=V7<0<8.


   70T<>4VO 7 V=H8<8 ;V:0@AL:8<8 70A>10<8 B0 V=HV 2848 270T<>4V9.

   V  2  O:>5  <>6=0  70AB>A>2C20B8 F5DB@80:A>= 7 :0;LFVT27G8=0<8 (@>7G8=
   V=35@0  B>I>). 0;LFVT27G8=8 =5 A;V4 ?@87=0G0B8 ?@>BO3>< 48 3>48= ?VA;O
   >AB0==L>3> 22545==O F5DB@80:A>=C.

   #  =>2>=0@>465=8E  B0  =54>=>H5=8E  4VB59  >?8A0=V  28?04:8 28=8:=5==O
   ?@5F8?VB0BV2 C ;535=OE B0 =8@:0E, O:V A?@8G8=8;8 ;5B0;L=V =0A;V4:8 ?@8
   >4=>G0A=>=C B0 ?@5?0@0BV2 :0;LFVN.

   @8  >4=>G0A=>AC20==V  28A>:8E  4>7  F5DB@80:A>=C  V B0:8E A8;L=>4VNG8E
   4VC@5B8:V2,  O:  DC@>A5@CH5=L  DC=:FVW  =8@>:  =5 A?>AB5@V30;>AO. 5<0T
   2:07V2>:   =0   B5,   I>   F5DB@80:A>=  ?V428ICT  =8@:>2C  B>:A8G=VABL
   03;V:>784V2.  VA;O  ?@89>3>;N  >4@07C  ?VA;O ?@89>=C =5 A?>AB5@V30;>AO
   5D5:BV2, AE>68E =0 4VN 48AC;LDV@0

   &5DB@80:A>= =5 B5B@07>;L=C 3@C?C, O:0 1 <>3;0 A?@8G8=8B8 =5?5@5=>A8;C,
   0  B0:>6 :@>2>B5GV, I> 2;0AB82> 45O:8< V=H8< F5D0;>A?>@8=0<. @>15=5F84
   =5 2?;820T =0 282545==O F5DB@80:A>=C.

   In vitro 1C2 28O2;5=89 0=B03>=V7< @0;>< B0 F5DB@80:A>=><.

   5 <>6=0 28:>@8AB>2C20B8 @>7G8==8:8, O:V 7G8= V=35@0 G8 @>7G8= 0@B<0=0,
   4;O  @>7G8=5==O F5DB@80:A>=C C D;0:>=0E G8 4;O @>72545==O 2V4=>2;5=>3>
   @>7G8=C   4;O  2=CB@VH=L>25==>3>  22545==O  C  72O7:C  7  2V@>3V4=VABN
   CB2>@5==O   ?@5F8?VB0BV2   :0;LFVT28E  A>;59  F5DB@80:A>=C.  8=8:=5==O
   ?@5F8?VB0BV2  :0;LFVT28E  A>;59  F5DB@80:A>=C  B0:>6 <>6;825 ?@8 7=C 7
   @>7G8=0<8,  O:V  4=V9 V=DC7V9=V9 A8AB525==>3> 22545==O. &5DB@80:A>= =5
   <>6=0   22>48B8   2=CB@VH=L>25==>   >4=>G0A=>  7  @>7G8=0<8,  O:V  AV1
   70AB>AC20==O  B0  4>78»).  >A;V465==O in vitro ?>:070;8, I> C =5<>2;OB
   ?V428I5=89 @878: CB2>@5==O ?@5F8?VB0BV2 :0;LFVT28E A>;59 F5DB@80:A>=C.

   3V4=>  7 ;VB5@0BC@=8<8 40=8<8, F5DB@80:A>= =5AC<, 20=:><, D;C:>=07>;><
   B0 03;V:>7840<8.

   0:B5@V>AB0B8G=V   70A>18   <>6CBL   2?;820B8   =0   10:B5@8F84=C   4VN
   F5D0;>A?>@8=V2.

   &5DB@80:A>=  <>65  7<5=HC20B8  5D5:B82=VABL  3>@<>=0;L=8E  ?5@>@0;L=8E
   :>=B@0F5?B82V2.  # 72O7:C 7 F8< @5:><5=4CTBLAO 70AB>A>2C20B8 4>40B:>2V
   (=53>@<>=0;L=V) <5B>48 :>=B@0F5?FVW ?V4 G0A ;V:C20==O B0 ?@>BO3>< 1

   5<0T  ?>2V4><;5=L  ?@>  270T<>4VN  =><  B0 ?@>4C:B0<8 4;O ?5@>@0;L=>3>
   ?@89>4VN  =><  ?@8  2=CB@VH=L>2V9  V=T:FVW  V ?@>4C:B0<8, O:V 25==> G8
   ?5@>@0;L=>).


   $0@<0:>;>3VG=V 2;0AB82>ABV.

   $0@<0:>48=0&5DB@80:A>=  ?0@5=B5@0;L=89 F5D0;>A?>@8=>289 0=B81V>B8: III
   ?>:>;V==O 7 ?@>;>=3>20=>N 4VTN.

   0:B5@8F84=0  0:B82=VABL  F5DB@80:A>=C  7C<>2;5=0  ?@83=VG5==O< A8=B57C
   :;VB8==8E  <5<1@0=.  &5DB@80:A>=  0:B82=89 in vitro 2V4=>A=> 1V;LH>ABV
   3@0<=530B82=8E  V  3@078B82=8E  >@30=V7= E0@0:B5@87CTBLAO 4C65 25;8:>N
   ABV9:VABN   4>   1V;LH>ABV   b-;0:B0<07   (O:   ?5=VF8;V=07,   B0:   V
   F5D0;>A?>@8=07)  3@078B82=8E  V  3@0<=530B82=8E  10:B5@V9. &5DB@80:A>=
   0:B82=89   I>4>   =86G5707=0G5=8E  >@30=V7in  vitro  V  ?@8  :;V=VG=8E
   V=D5:FVOE (482. «>:070==O»).

   @078B82=V    05@>18:   Staphylococcus   aureus   (<5B8F8;V=>GCB;8289),
   :>03C;07>=530B82=V     AB0DV;>:>:8,       Streptococcus       pyogenes
   (?-35<>;VB8G=89,    3@C?8    ),    Streptococcus    agalactiae

   (?-35<>;VB8G=89, 3@C?8 ), ?-35<>;VB8G=V AB@5?B>:>:8 (>:@V< 3@C?8 B0 ),
   Streptococcus viridans, Streptococcus pneumoniae.

   @8   !BV9:V   4>   <5B8F8;V=C   Staphylococcus   spp.  @578AB5=B=V  4>
   F5D0;>A?>@8=V2,  C  B>   G8A;V  4>  F5DB@80:A>=C.  "0:>6  Enterococcus
   faecalis,  Enterococcus  faecium  B0  Listeria monocytogenes 28O2;ONBL
   ABV9:VABL 4> F5DB@80:A>=C.

   @0<=530B82=V  05@>18:  Acinetobacter  lwoffi,  Acinetobacter anitratus
   (3>;>2=8<  G8=><  A.  baumanii)*,  Aeromonas  hydrophila,  Alcaligenes
   faecalis,  Alcaligenes  odorans,  0;:035=>?>4V1=V  10:B5@VW,  Borrelia
   burgdorferi,   Capnocytophaga   spp.,  Citrobacter  diversus  (C  B>C.
   amalonaticus),  Citrobacter  freundii*, Escherichia coli, Enterobacter
   aerogenes*,   Enterobacter   cloacae*,   Enterobacter   spp.  (V=HV)*,
   Haemophilus     ducreyi,     Haemophilus    influenzae,    Haemophilus
   parainfluenzae,   Hafnia   alvei,   Klebsiella   oxytoca,   Klebsiella
   pneumoniae**,  Moraxella  catarrhalis  (@0=VH5  =07820;8AO Branhamella
   catarrhalis),  Moraxella  osloensis, Moraxella spp. (V=HV), Morganella
   morganii,  Neisseria  gonorrhoea,  Neisseria meningitidis, Pasteurella
   multocida,   Plesiomonas   shigelloides,  Proteus  mirabilis,  Proteus
   penneri*,  Proteus  vulgaris*,  Pseudomonas  fluorescens*, Pseudomonas
   spp.   (V=HV)*,   Providentia   rettgeri*,  Providentia  spp.  (V=HV),
   Salmonella  typhi, Salmonella spp. (=5B8D>W4=V), Serratia marcescens*,
   Serratia   spp.   (V=HV)*,   Shigella   spp.,  Vibrio  spp.,  Yersinia
   enterocolitica, Yersinia spp. (V=HV).

   *  5O:V  V7>;OB8  F8E  284V2  ABV9:V  4>  F5DB@80:A>=C, 3>;>2=8< G8=><
   C=0A;V4>: CB2>@5==O ?-;0:B0<07, I> :>4CNBLAO E@><>A><0<8;

   **  45O:V V7>;OB8 F8E 284V2 ABV9:V 4> F5DB@80:A>=C 2=0A;V4>: CB2>@5==O
   =87:8 ?;07->?>A5@54:>20=8E ?-;0:B0<07.

   @8  030B>  7V  HB0>@30=V768==C  ABV9:VABL  4>  B0:8E 0=B81V>B8:V2,  O:
   0?5=VF8;V=8  B0  C@5W4>?5=VF8;V=8,  F5D0;>A?>@8=8  ?5@H>3>  B0 4@C3>3>
   ?>:>;V==O, 03;V:>7848, T GCB;828<8 4> F5DB@80:A>=C. Treponema pallidum
   GCB;820  4>  F5DB@80:A>=C  in  vitro V 2 4>A;V40E =0 B20@8=0E. ;V=VG=V
   28?@>1C20==O  ?>:07CNBL,  I>  F5DB@80:A>=  5D5:B82=89   4;O  ;V:C20==O
   ?5@28==>3>  V  2B>@8==>3>  A8DV;VAC,   70   28=OB:><   :;V=VG=8E   HB0

   P. 0eruginosa, ABV9:8E 4> F5DB@80:A>=C.

   =05@>18:  Bacteroides spp. (GCB;82V 4> 6>2GV)*, Clostridium spp. (:@V<
   C.  difficile),  Fusobacterium  nucleatum,  Fusobacterium spp. (V=HV),
   Gaffkia anaerobica (@0=VH5 =07820;8AO Peptococcus), Peptostreptococcus
   spp.

   *  5O:V  V7>;OB8  F8E 284V2 ABV9:V 4> F5DB@80:A>=C 2=0A;V4>: CB2>@5==O
   ?-;0:B0<07.

   @8  030B> 7V HB0 Bacteroides spp., O:V ?@>4C:CNBL b-;0:B0<078 (7>:@5<0
    B. fragilis), ABV9:V 4> F5DB@80:A>=C. !BV9:89 Clostridium difficile.

   'CB;82VABL  4> F5DB@80:A>=C <>6=0 287=0G0B8 <5B>4>< 48A:V2 01> <5B>4><
   A5@V9=8E  @>72545=L  =0  030@V 01> 1C;L9>=V, 28:>@8AB>2CNG8 AB0=40@B=C
   <5B>48:C,  ?>4V1=C  4>  BVTW,  O:C  @5:><5=4CT  0FV>=0;L=89 :>@0B>@=8E
   AB0=40@BV2  (!).  ;O  F5DB@80:A>=C  !  2AB0=>282  B0:V :@8B5@VW >FV=:8
   @57C;LB0BV2 28?@>1C20=L:



                                                'CB;82V

                                                                                         >

                                                                                      GCB;82V

                                                                                              !BV9:V

                            5B>4 @>72545=L

                     =3V1CNG0 :>=F5=B@0FVO, <3/;


                                                                                  8



                                                       16-32


                                                                                                64

                             5B>4 48A:V2

                            (48A: 7 30 =C)

                       V0<5B@ 7>=8 70B@8ABC, <<


                                                                                  21


                                                                                       20-14


                                                                                                13


   ;O  287=0G5==O  GCB;82>ABV  >@30=V7@8AB>2C20B8  48A:8 7 F5DB@80:A>=><,
   >A:V;L:8   4>A;V465==O  in  vitro  ?>:070;8,  I>  F5DB@80:A>= 0:B82=89
   2V4=>A=>  >:@5<8E  HB0@8AB0==V  48A:V2,  ?@87=0G5=8E  4;O  2AVTW 3@C?8
   F5D0;>A?>@8=V2.

   0!  4;O  287=0G5==O GCB;82>ABV >@30=V76=0 28:>@8AB>2C20B8 9 V=HV 4>1@5
   AB0=40@B87>20=V  =>@<0B828,  =0?@8:;04 DIN B0 ICS, I> 40NBL <>6;82VABL
   045:20B=> >FV=8B8 @V25=L GCB;82>ABV.

   $0@<0:>:V=5B8:0. $0@<0:>:V=5B8:0 F5D@B80:A>=C <0T =5;V=V9=89 E0@0:B5@.
   AV  >A=>2=V  D0@<0:>:V=5B8G=V  ?0@0<5B@8,  I>  107CNBLAO  =0 7030;L=8E
   :>=F5=B@0FVOE  ?@5?0@0BC, 70 28=OB:>< ?5@V>4C =0?V2282545==O, 70;560BL
   2V4 4>78.

   &5DB@80:A>=   2V4@V7=OTBLAO  B@820;8<  G0A><  =0?V2282545==O,  O:89  C
   74>@>28E   4>@>A;8E   AB0=>28BL   ?@81;87=>   8   3>48=.    0:A8<0;L=0
   :>=F5=B@0FVO  C  ?;072V ?VA;O >4=>@07>2>3> 2=CB@VH=L>2>3> 22545==O 1 3
   ?@5?0@0BC  AB0=>28BL  81  <3/;  B0  4>AO30TBLAO  70  2-3  3>48=8 ?VA;O
   22545==O.   >=F5=B@0FVO  C  ?;072V  ?VA;O  2=CB@VH=L>25==>3>  22545==O
   4>@V2=NT   B0:V9   ?VA;O   2=CB@VH=L>2>3>  22545==O.  &5  >7=0G0T,  I>
   1V>4>ABC?=VABL  F5DB@80:A>=C  ?VA;O  2=CB@VH=L>2>3> 22545==O AB0=>28BL
   100  %.  VA;O 2=CB@VH=L>25==>3> 22545==O F5DB@80:A>= H284:> ?@>=8:0T C
   B:0=8==C  @V48=C, 45 ?@>BO3>< 1V;LH =V6 24 3>48= ?V4B@8=F5=B@0FVW I>4>
   GCB;828E  >@30=V72G>282V4=8E  H;OE0E, ?5GV=FV, <8340;8:0E, A5@54=L>2V9
   =>A0,  :VAB:0E,  0  B0:>6  A?8==><>7:>2V9, ?;52@0;L=V9 B0 A8=>2V0;L=V9
   @V48=0E, C A5:@5BV ?@>AB0B8).

   82545==O.

   5@V>4   =0?V2282545==O  F5DB@80:A>=C  C  74>@>28E  4>@>A;8E  AB0=>28BL
   ?@81;87=>  8  3>48=.  030;L=89 ?;07<>289 :;V@5=A F5DB@80:A>=C 4>@V2=NT
   10-22 <;/E2. 8@:>289 :;V@5=A 4>@V2=NT 5-12 <;/E2. # =5<>2;OB C ?5@HV 8
   4=V2  68BBO, 0 B0:>6 2 >AV1 2V:>< ?>=04 75 @>:V2 ?5@V>4 =0?V2282545==O
   2  A5@54=L>@>A;8E  <>;>4>3>  2V:C.    #  4>@>A;8E 50-60 % F5DB@80:A>=C
   282>48BLAO  C  =572GN. 8H:>20 D;>@0 ?5@5B2>@NT F5DB@80:A>= C =50:B82=V
   <5B01>;VB8.  #  =>2>=0@>465=8E =8@:0<8 282>48BLAO ?@81;87=> 70 % 4>78.
   #  E2>@8E  V7  =8@:>2>N  01>  ?5GV=:>2>N =54>AB0B=VABN D0@<0:>:V=5B8:0
   F5DB@80:A>=C  7N  N,  2V47=0G0TBLAO  ;8H5  =57=0G=5 71V;LH5==O ?5@V>4C
   =0?V2282545==O.   /:I>   ?>@CH5=0  ;8H5  DC=:FVO  =8@>:,  71V;LHCTBLAO
   282545==O   7  6>2GN,  O:I>  ?>@CH5=0  DC=:FVO  ?5GV=:8,  71V;LHCTBLAO
   282545==O =8@:0<8.

   2O7C20==O 7 1V;:0<8.

   &5DB@80:A>=  >1>@>B=>  72O7CTBLAO 7 0;L1C<, ?@8G>AB0==O< :>=F5=B@0FVW,
   =0?@8:;04  7=86CTBLAO  7  95 %  ?@8  :>=F5=B@0FVW  C  ?;072V <5=H5 100
   <3/;  4>  85  %  ?@8 :>=F5=B@0FVW 300 <3/;. 024O:8 =86GV9 :>=F5=B@0FVW
   0;L1C3> F5DB@80:A>=C 2 =V9 28I0, =V6 C ?;072V.

   @>=8:=5==O C F5@51@>A?V=0;L=C @V48=C.

   #  4VB59,  C  B>2>=0@>465=8E,  F5DB@80:A>= ?@>=8:0T C 70?0;5=V <>7:>2V
   >1>;>=:8.  0:A8<0;L=0 :>=F5=B@0FVO C A?8==><>7:>2V9 @V48=V 4>AO30TBLAO
   ?@81;87=> G5@57 4 3>48=8 ?VA;O 2=CB@VH=L>25==>3> 22545==O B0 AB0=>28BL
   C  A5@54=L>=F5=B@0FVO   F5DB@80:A>=C  C  F5@51@>A?V=0;L=V9  @V48=V ?@8
   10:B5@V0;L=>28BL  17  %  2V4 :>=F5=B@0FVW C ?;072V, I> <0965 2  4 @078
   ?5@528ICT   :>=F5=B@0FVN  ?@8  0A5?B8G=>48=8  ?VA;O  2=CB@VH=L>25==>3>
   22545==O    F5DB@80:A>=C   C   4>7V   50-100   <3/:3   <0A8   BV;0   C
   F5@51@>A?V=0;L=V9  @V48=V  A?>AB5@V30NBLAO  :>=F5=B@0FVW F5DB@80:A>=C,
   O:V  ?5@528ICNBL  1,4  <3/;.  #  4>@>A;8E  E2>@8E  7  <5=V=3VB>< ?VA;O
   22545==O  4>78  50  <3/:3 <0A8 BV;0 G5@57 2-24 3>48=8 4>AO30NBLAO B0:V
   :>=F5=B@0FVW  F5DB@80:A>=C  C  F5@51@>A?V=0;L=V9  @V48=V, O:V 2 1030B>
   @07V2   ?5@528ICNBL   =F5=B@0FVW   4;O  =09@>7?>2AN465=VH8E  71C4=8:V2
   <5=V=3VBC.

   &5DB@80:A>= ?@>=8:0T :@V7L ?;0F5=B0@=89 10@T@ B0 C <0;8E :>=F5=B@0FVOE
   C 3@C4=5 <>;>:>.

   5B01>;V7<

   &5DB@80:A>=  =5  ?V440TBLAO  A8AB5<=>;V7@NTBLAO C =50:B82=V <5B01>;VB8
   ?V4 4VTN :8H:>2>W D;>@8.


   $0@<0F52B8G=V E0@0:B5@8AB8:8.

   A=>2=V  DV78:>-EVABV:  :@8AB0;VG=89 ?>@>H>: <0965 1V;>3> 01> 6>2B02>3>
   :>;L>@C. !;01:> 3V3@>A:>?VG=89.


   5AC

   &5DB@80:A>=  =5  <>6=0  77G8=0<8,  B0:8<8  O:  @>7G8= V=35@0 G8 @>7G8=
   0@B<0=0.

   &5DB@80:A>= =5AC<, 20=:><, D;C:>=07>;>< V 03;V:>7840<8.

   5   A;V4  77G8==8:0<8,  :@V<  B8E,  I>  707=0G5=V  2  @>74V;V  «!?>AV1
   70AB>AC20==O B0 4>78».


   "5@ABV. 2 @>:8


   #<>28 715@V30==O.

   15@V30B8 2 >@83V=0;L=V9 C?0:>2FV ?@8 B5

   15@V30B8 C =54>ABC?=>

   @83>B>2;5=89 @>7G8= 715@V30B8 2 70E8I5=>BO3>< 6 3>48= ?@8 :V<=0B=V9 B5
   ?@>BO3>< 24 3>48= ?@8 B5




   #?0:>2:0.

   1 3 C D;0:>=V (10 <;) 1 2 :0@B>==V9 ?0GFV.


   0B53>@VO 2V4?CA:C. 0 @5F5?B><.


   8@>1=8:.

   «01>@0B>@V> 5V3 >D@5, C.A», A?0=VO /

   «Laboratorio Reig Jofre, S.A.», Spain.


   VAF57=0E>465==O.

   2C;. 5@5<0, 111, ?@><8A;>20 7>=0, ">;54>, 45007 (">;54>), A?0=VO /

   C/Jarama 111, Poligono Industrial, Toledo, 45007 (Toledo), Spain.

Данный продукт не является частью других товаров.


Комментарии Алвобак пор. д/ин. 1000 мг фл. №1

Отзывы Алвобак пор. д/ин. 1000 мг фл. №1

К сожалению, отзывов еще нет, Вы можете стать первым!

Добавить отзыв

Рекомендуем

Прана-Фарм Интернет аптека, заказ лекарств, продажа медикаментов
(050)490-490-0 (068)111-77-49 (057)766-72-60 (0536)703-226 (0542)79-28-20
Пн-Пт: 8.30-18.00